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human jagged2  (R&D Systems)


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    R&D Systems human jagged2
    Human Jagged2, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 27 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/recombinant+human+jagged2+fc/Recombinant+Human+Jagged+2+Fc+Chimera+Protein%2C+CF/us11897965-1155-45-52
    Average 93 stars, based on 27 article reviews
    human jagged2 - by Bioz Stars, 2026-09
    93/100 stars

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    Recombinant:

    Article Title: Rheumatoid arthritis-associated RBPJ polymorphism alters memory CD4 + T cells
    Article Snippet: T cells were plated equally at 20 000–50 000 cells per well on 96-well round bottom polystyrene culture plates (Costar). .. Recombinant human Jagged2-Fc, DLL4-Fc and control IgG were purchased from R&D Systems. .. Naïve and memory CD4 + T cells were incubated at 37°C (5% CO 2 ) for 0 h, 3 h or 7 days in RPMI 1640 Medium (Gibco) with plate-bound Jagged2-Fc, DLL4-Fc or IgG (2 μg/ml) in the presence of immobilized anti-CD3 [OKT3 (trade name Orthoclone)]/soluble CD28 (1 μg/ml) (Biolegend) and soluble IL-2 (20 U/ml).

    Control:

    Article Title: Rheumatoid arthritis-associated RBPJ polymorphism alters memory CD4 + T cells
    Article Snippet: T cells were plated equally at 20 000–50 000 cells per well on 96-well round bottom polystyrene culture plates (Costar). .. Recombinant human Jagged2-Fc, DLL4-Fc and control IgG were purchased from R&D Systems. .. Naïve and memory CD4 + T cells were incubated at 37°C (5% CO 2 ) for 0 h, 3 h or 7 days in RPMI 1640 Medium (Gibco) with plate-bound Jagged2-Fc, DLL4-Fc or IgG (2 μg/ml) in the presence of immobilized anti-CD3 [OKT3 (trade name Orthoclone)]/soluble CD28 (1 μg/ml) (Biolegend) and soluble IL-2 (20 U/ml).



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    NOTCH3 L1519P produces ICD in a ligand-independent manner. (A) Western blot analysis of FL, TMIC and NEXT and ICD fragments from cell extracts using an anti-NOTCH3 ICD antibody, following activation of the cells by immobilized <t>jagged2</t> (Jag2-Fc) and treatment with the γ-secretase inhibitor DAPT or MG132, as indicated. (B) NIH3T3 cells were transfected with wild-type, NOTCH3 L1519P or control plasmid together with 12XCSL-luc reporter and β-gal plasmids and cultured on immobilized jagged2 (Jag2) in combination with treatment by DMSO or DAPT, as indicated ( n =3). Statistical analysis was performed from three experiments using paired Student's t -test, * P <0.1, ** P <10 −2 , *** P <10 −3 , RLU, relative luminescence units.
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    NOTCH3 L1519P produces ICD in a ligand-independent manner. (A) Western blot analysis of FL, TMIC and NEXT and ICD fragments from cell extracts using an anti-NOTCH3 ICD antibody, following activation of the cells by immobilized <t>jagged2</t> (Jag2-Fc) and treatment with the γ-secretase inhibitor DAPT or MG132, as indicated. (B) NIH3T3 cells were transfected with wild-type, NOTCH3 L1519P or control plasmid together with 12XCSL-luc reporter and β-gal plasmids and cultured on immobilized jagged2 (Jag2) in combination with treatment by DMSO or DAPT, as indicated ( n =3). Statistical analysis was performed from three experiments using paired Student's t -test, * P <0.1, ** P <10 −2 , *** P <10 −3 , RLU, relative luminescence units.
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    Image Search Results


    NOTCH3 L1519P produces ICD in a ligand-independent manner. (A) Western blot analysis of FL, TMIC and NEXT and ICD fragments from cell extracts using an anti-NOTCH3 ICD antibody, following activation of the cells by immobilized jagged2 (Jag2-Fc) and treatment with the γ-secretase inhibitor DAPT or MG132, as indicated. (B) NIH3T3 cells were transfected with wild-type, NOTCH3 L1519P or control plasmid together with 12XCSL-luc reporter and β-gal plasmids and cultured on immobilized jagged2 (Jag2) in combination with treatment by DMSO or DAPT, as indicated ( n =3). Statistical analysis was performed from three experiments using paired Student's t -test, * P <0.1, ** P <10 −2 , *** P <10 −3 , RLU, relative luminescence units.

    Journal: Disease Models & Mechanisms

    Article Title: The infantile myofibromatosis NOTCH3 L1519P mutation leads to hyperactivated ligand-independent Notch signaling and increased PDGFRB expression

    doi: 10.1242/dmm.046300

    Figure Lengend Snippet: NOTCH3 L1519P produces ICD in a ligand-independent manner. (A) Western blot analysis of FL, TMIC and NEXT and ICD fragments from cell extracts using an anti-NOTCH3 ICD antibody, following activation of the cells by immobilized jagged2 (Jag2-Fc) and treatment with the γ-secretase inhibitor DAPT or MG132, as indicated. (B) NIH3T3 cells were transfected with wild-type, NOTCH3 L1519P or control plasmid together with 12XCSL-luc reporter and β-gal plasmids and cultured on immobilized jagged2 (Jag2) in combination with treatment by DMSO or DAPT, as indicated ( n =3). Statistical analysis was performed from three experiments using paired Student's t -test, * P <0.1, ** P <10 −2 , *** P <10 −3 , RLU, relative luminescence units.

    Article Snippet: Cell culture plates were coated with recombinant human jagged2 Fc chimeric protein (#P78504, R&D Systems) at 0.5 μg/ml, with IgG Fc fragment as control.

    Techniques: Western Blot, Activation Assay, Transfection, Control, Plasmid Preparation, Cell Culture